A New Paradigm: Quantitative Cell Biology

Our Center combines experimental and computational skills to build time + 3D whole cell models (4DWCM). The models contain a quantitative description of the physical and chemical processes within cells and organelles and develop and extend experimental methods to measure cell structure, chemical composition, and sub-cellular dynamics.

Models integrate information from 1) sub-cellular -omics and microscopy, 2) label-free IR imaging of metabolites, 3) cryo-electron tomography of cellular architecture, 4) describe fundamental biological processes from the coarse-grained to the all-atom levels, and 5) use super-intelligence and machine learning to analyze the cell behavior, biological data, improve imaging, and code development.

Funded by the National Science Foundation, the tools we build, the data we generate, and the methods we develop are made freely available. We’re driving the state-of-the-art, and sharing all our techniques, methods, and findings with researchers and students worldwide.