Angad’s team leads the chemical biology components of center research. His lab has created yeast mutants that alter mitochondrial function and could alter mitochondrial networks. He uses fluorescence confocal imaging to test the correlation between mitochondrial function or dysfunction genotypes to changes in the mitochondrial dynamics. His group collaborates with Rohit Bhargava’s lab to perform imaging studies to investigate how changes in yeast mitochondrial dynamics alter metabolism. Angad’s lab has generated transcriptomics data for the minimal cell (strain syn1), and is currently working with HPCBio and Zan Luthey-Schulten’s lab to analyze the transcriptional profile of the minimal cells. They are also working on generating more replicates of these transcriptomics datasets. This is expected to inform operons, operonic structure, and relative abundances of all the transcripts within the minimal cell. They have also worked with Taekjip Ha’s lab on imaging studies of the minimal cell to study its cell division process.
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