Minecraft

Visualizing Cell Structures with Minecraft

In recent years, the field of cellular biology has witnessed remarkable advancements in three-dimensional (3D) microscopic techniques, such as cryogenic soft x-ray tomography, cryogenic electron tomography (cryo-ET), and focused ion beam scanning electron microscopy, enabling visualization of subcellular structures with resolution in nanometers. The results provide valuable spatial distributions of different organelles and proteins, which can further facilitate the development of more realistic 3D whole-cell models (WCMs) for research and educational purposes, enhancing our understanding of cellular functions and the complicated chemical reactions within cells.

Many microscopic images and simulations of cells give results in different kinds of formats, making it difficult for people lacking computational skills to visualize and interact with them. Minecraft offers a unique solution by allowing the direct insertion of voxel-based (voxels are essentially 3D pixels) cellular structures from light microscopy and simulations into its worlds without modification.

This integration enables Minecraft players to immerse themselves into the cell, navigate through the cytoplasmic membrane, observe the spatial distribution of organelles, and gain a tangible understanding of relative sizes and quantities.

Download these Minecraft worlds and have fun learning more about cells!

Normal Cell: A 3D holotomographic image of hTERT-HME1 normal human breast cells was aqcuired using the 3D cell explorer microscope (Nanolive) and programmatically placed into minecraft.

normal

Cancer: A 3D holotomographic image of MDA-MB-231 human breast cancer cells was aqcuired using the 3D cell explorer microscope (Nanolive) and programmatically placed into Minecraft.

cancer

Cell tour: A 3D holotomographic image of MDA-MB-231 human breast cancer cells was aqcuired using the 3D cell explorer microscope (Nanolive) and programmatically placed into Minecraft.

cell tour

Martini: Parts of the minimal cell are shown/hidden to demonstrate how the cell fits together!

martini

Neutrophils: In your blood there are immune cells called neutrophils. Sequential 3D holotomographic images of human neutrophils were aqcuired using the 3D cell explorer microscope (Nanolive) and are programmatically placed into Minecraft in real-time.

neutrophils

Yeast: Electron tomography data of a yeast cell.

yeast

Rollercoaster: A rollercoaster ride through the minimal cell!

rollercoaster