We seek to quantitatively describe the physical and chemical processes that define the functional state of a cell with computer modeling and simulation.

Our Goal:

To make 4D (space plus time) computer models of whole cells functioning under normal and stressed conditions. The modeling will be guided by developing cutting-edge experimental tools that generate datasets with unprecedented resolution.

As to the computational component for the minimal bacterial cell, it ranges from Lattice Microbes simulations with 200,000 particles to the all-atom simulations with Martini/Gromacs for 2 billion particles. Only LM can simulate the entire cell cycle while the all-atom models will be simulated around specific states of the cell, e.g., before, during, and after cell division.